Article

ClairS: a deep-learning method for long-read somatic small variant calling

2023-08-21

Abstract excerpt

Identifying somatic variants in tumor samples is a crucial task, which is often performed using statistical methods and heuristic filters applied to short-read data. However, with the increasing demand for long-read somatic variant calling, existing methods have fallen short. To address this gap, we present ClairS, the first deep-learning-based, long-read somatic small variant caller. ClairS was trained on massive...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d142ece5-dfde-5a21-aae1-551b95d17ffa
DOI: 10.1101/2023.08.17.553778

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ClairS: a deep-learning method for long-read somatic small variant callingDOI 10.1101/2023.08.17.553778Read

ClairS: a deep-learning method for long-read tumor-normal pair somatic small variant calling.Semantic proximity Read

ClairS-TO: A deep-learning method for long-read tumor-only somatic small variant callingSemantic proximity Read

DeepSomatic: Accurate somatic small variant discovery for multiple sequencing technologiesSemantic proximity Read

Cost-effective hybrid long- and short-read sequencing enables accurate somatic structural variant detectionSemantic proximity Read

DeepSSV: detecting somatic small variants in paired tumor and normal sequencing data with convolutional neural network.Semantic proximity Read

DeepSSV: detecting somatic small variants in paired tumor and normal sequencing data with convolutional neural networkSemantic proximity Read

Lancet2: Improved and accelerated somatic variant calling with joint multi-sample local assembly graphs.Semantic proximity Read

RNAIndel: discovering somatic coding indels from tumor RNA-Seq dataSemantic proximity Read

TNscope: Accurate Detection of Somatic Mutations with Haplotype-based Variant Candidate Detection and Machine Learning FilteringSemantic proximity Read

Lancet2: Improved and accelerated somatic variant calling with joint multi-sample local assembly graphsSemantic proximity Read

Detection of somatic structural variants from short-read next-generation sequencing data.Semantic proximity Read

SAVANA: reliable analysis of somatic structural variants and copy number aberrations in clinical samples using long-read sequencingSemantic proximity Read