Article

Pansoma, a machine learning tool for identifying somatic variants using pangenome graphs

2026-05-29

Abstract excerpt

Somatic variant calling, the identification of mutations in non-germline cells acquired over an individual’s lifetime, is critical for studying diseases, including cancer, and for developing precision oncology strategies. Traditional somatic variant calling methods rely on linear reference genomes, which do not adequately capture human genetic diversity and result in reference bias, compromising the accuracy of so...

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Literature Corpus work: 87d13070-4f0e-5823-a931-afdcc1bdbdf4
DOI: 10.64898/2026.05.27.726245

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