Article
Comprehensive analysis of BIRC5: from pan-cancer analysis to experimental validation.
BMC cancer - 8 Dec 2025
Liao Guoliang, Qian Jiekun, Wei Shijie, Yan Xin, Liu Qing, Huang Qinzhao, Lin Yuxing, Xu Guobing, Zheng Bin, Chen Chun, Yang Zhang
Abstract excerpt
BACKGROUND: Baculoviral inhibitor of apoptosis protein repeat-containing protein 5 (BIRC5), also known as survivin, belongs to the inhibitor of apoptosis proteins (IAP) family and serves as a key regulator of cellular survival and programmed cell death. Current research has demonstrated that BIRC5 exhibits high expression levels in many cancers. Furthermore, its overexpression significantly correlates with poor...
Topics
- Humans
- Survivin
- Gene Expression Regulation, Neoplastic
- Neoplasms
- Prognosis
- DNA Methylation
- Cell Line, Tumor
- Cell Proliferation
- Biomarkers, Tumor
- Mutation