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Article

Comprehensive analysis of BIRC5: from pan-cancer analysis to experimental validation.

BMC cancer - 8 Dec 2025

Liao Guoliang, Qian Jiekun, Wei Shijie, Yan Xin, Liu Qing, Huang Qinzhao, Lin Yuxing, Xu Guobing, Zheng Bin, Chen Chun, Yang Zhang

Abstract excerpt

BACKGROUND: Baculoviral inhibitor of apoptosis protein repeat-containing protein 5 (BIRC5), also known as survivin, belongs to the inhibitor of apoptosis proteins (IAP) family and serves as a key regulator of cellular survival and programmed cell death. Current research has demonstrated that BIRC5 exhibits high expression levels in many cancers. Furthermore, its overexpression significantly correlates with poor...

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Identifiers

PMID: 41361777
DOI: 10.1186/s12885-025-15184-8
PMCID: PMC12683835

Genes

CCK

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