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BIRC5 as a master regulator in HCC: unraveling its role in tumor survival and therapeutic potential

5 Jun 2025

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal malignancies worldwide, with limited effective therapeutic options. Identifying novel targets is crucial for improving treatment strategies. In this study, we integrated bioinformatics and experimental approaches to uncover key regulatory genes in HCC. BIRC5 (survivin) emerged as a central hub gene, playing a pivotal role in apoptosis...

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PMID: 40471223
DOI: 10.1007/s10142-025-01615-z

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