Article

Structural dynamics of AAA+ ATPase Drg1 and mechanism of benzo-diazaborine inhibition

2022-01-07

Abstract excerpt

<title>Abstract</title> <p>The AAA+ ATPase Drg1 is a ribosome assembly factor in yeast, and functions to release Rlp24, another assembly factor, from the pre-60S particle just exported from nucleus to initiate its further cytoplasmic maturation. Being a type II AAA+ protein with two ATPase domains (D1 and D2), its activity in ribosome assembly can be inhibited by a drug molecule diazaborine. In human, mutations o...

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Literature Corpus work: fdafa0ce-7d64-5fbb-9f81-1c32a2d50263
DOI: 10.21203/rs.3.rs-1181322/v1

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