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Article

Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine.

Nature communications - 9 Jun 2021

Prattes Michael, Grishkovskaya Irina, Hodirnau Victor-Valentin, Rössler Ingrid, Klein Isabella, Hetzmannseder Christina, Zisser Gertrude, Gruber Christian C, Gruber Karl, Haselbach David, Bergler Helmut

Abstract excerpt

The hexameric AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis and initiates cytoplasmic maturation of the large ribosomal subunit by releasing the shuttling maturation factor Rlp24. Drg1 monomers contain two AAA-domains (D1 and D2) that act in a concerted manner. Rlp24 release is inhibited by the drug diazaborine which blocks ATP hydrolysis in D2. The mode of inhibition was unknown. Here we show...

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PMID: 34108481
DOI: 10.1038/s41467-021-23854-x
PMCID: PMC8190095

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