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Article

Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

Journal of molecular biology - 29 Jul 2014

Chou Tsui-Fen, Bulfer Stacie L, Weihl Conrad C, Li Kelin, Lis Lev G, Walters Michael A, Schoenen Frank J, Lin Henry J, Deshaies Raymond J, Arkin Michelle R

Abstract excerpt

The p97 AAA (ATPase associated with diverse cellular activities), also called VCP (valosin-containing protein), is an important therapeutic target for cancer and neurodegenerative diseases. p97 forms a hexamer composed of two AAA domains (D1 and D2) that form two stacked rings and an N-terminal domain that binds numerous cofactor proteins. The interplay between the three domains in p97 is complex, and a deeper...

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Identifiers

PMID: 24878061
DOI: 10.1016/j.jmb.2014.05.022
PMCID: PMC4102644

Genes

VCP
NMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.PMID 24878061Read ↗

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