Article

Genomic Analysis of Human Brain Metastases Treated with Stereotactic Radiosurgery Under the Phase-II Clinical Trial (NCT03398694) Reveals DNA Damage Repair at the Peripheral Tumor Edge

2023-04-20

Abstract excerpt

Stereotactic Radiosurgery (SRS) is one of the leading treatment modalities for oligo brain metastasis (BM), however no comprehensive genomic data assessing the effect of radiation on BM in humans exist. Leveraging a unique opportunity, as part of the clinical trial ( NCT03398694 ), we collected post-SRS, delivered via Gamma-knife or LINAC, tumor samples from core and peripheral-edges of the resected tumor to char...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd983565-74a2-5f96-8e91-dc90d2f8e980
DOI: 10.1101/2023.04.15.23288491

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic Analysis of Human Brain Metastases Treated with Stereotactic Radiosurgery Under the Phase-II Clinical Trial (NCT03398694) Reveals DNA Damage Repair at the Peripheral Tumor EdgeDOI 10.1101/2023.04.15.23288491Read

Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance.Semantic proximity Read

Sequencing brain metastases and opportunities for targeted therapies.Semantic proximity Read

The genetic landscape of gliomas arising after therapeutic radiation.Semantic proximity Read

A genomic score to predict local control among patients with brain metastases managed with radiation.Semantic proximity Read

Treatment of brain metastases in the modern genomic era.Semantic proximity Read

Genomic analysis reveals secondary glioblastoma after radiotherapy in a subset of recurrent medulloblastomasSemantic proximity Read

Genomic profiling of brain metastases: current knowledge and new frontiers.Semantic proximity Read

Radiogenomics of Stereotactic Radiotherapy: Genetic Mechanisms Underlying Radiosensitivity, Resistance, and Immune ResponseSemantic proximity Read

An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinasesSemantic proximity Read

The impact of radiation on glioblastoma evolutionSemantic proximity Read

Single-Cell Multiomic Profiling Uncovers Radiation Dosage-Sensitive, Cluster-Specific Regulatory Dynamics in GlioblastomaSemantic proximity Read

Ex-vivo drug screening of surgically resected glioma stem cells to replace murine avatars and provide personalise cancer therapy for glioblastoma patientsSemantic proximity Read