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Article

A genomic score to predict local control among patients with brain metastases managed with radiation.

Neuro-oncology - 3 Oct 2023

Lamba Nayan, Cagney Daniel N, Catalano Paul J, Kim Dewey, Elhalawani Hesham, Haas-Kogan Daphne A, Wen Patrick Y, Wagle Nikhil, Aizer Ayal A

Abstract excerpt

BACKGROUND: Clinical predictors of local recurrence following radiation among patients with brain metastases (BrM) provide limited explanatory power. We developed a DNA-based signature of radiotherapeutic efficacy among patients with BrM to better characterize recurrence risk. METHODS: We identified 570 patients with 1487 BrM managed with whole-brain (WBRT) or stereotactic radiation therapy at Brigham and Women's...

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Identifiers

PMID: 37260393
DOI: 10.1093/neuonc/noad098
PMCID: PMC10547520

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