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First Generation Tools for the Modeling of Capicua (CIC) - Family Fusion Oncoprotein-Driven Cancers

2025-05-14

Abstract excerpt

<h4>Summary</h4> Clinical divergence between patients harboring CIC-rearrangements is frequently observed. For example, the prototypical CIC::DUX4 fusion associates with soft tissue tumors while CIC::NUTM1 fusions typically localize to the CNS (brain/spinal cord). The basis for these differences is poorly understood due to a lack of molecular tools. To address this need, we generated patient-informed, synthetic c...

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Literature Corpus work
ae73f814-012f-5872-a54e-635e952cffd6
DOI
10.1101/2025.05.13.653825
Open publication

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First Generation Tools for the Modeling of Capicua (CIC) - Family Fusion Oncoprotein-Driven CancersDOI 10.1101/2025.05.13.653825
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