Article

WEE1 kinase is a therapeutic vulnerability in CIC-DUX4 undifferentiated sarcoma

2021-06-22

Abstract excerpt

CIC-DUX4 rearrangements define an aggressive and chemotherapy-insensitive subset of undifferentiated sarcomas. The CIC-DUX4 fusion drives oncogenesis through direct transcriptional upregulation of cell cycle and DNA replication genes. Notably, CIC-DUX4- mediated CCNE1 upregulation compromises the G1/S transition, conferring a potential survival dependence on the G2/M cell cycle checkpoint. Through an integrative...

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Literature Corpus work: 347e81b1-4c01-5353-b66a-9d352a23ad43
DOI: 10.1101/2021.06.21.448439

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