Article

Ketamine improves anhedonic phenotypes across species: Translational evidence from the Probabilistic Reward Task

2025-06-03

Abstract excerpt

<h4>Background</h4> Ketamine is increasingly used as a therapeutic option for treatment-resistant depression (TRD) due to its rapid antidepressant properties, yet the mechanisms underlying these effects remain elusive. Preclinical evidence suggests ketamine acts on neural pathways implicated in reward processing, but translational efforts have proven challenging, due to a lack of paradigms allowing for analogous a...

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Literature Corpus work: d55ea6a3-3707-5e83-aa08-b96b334d736e
DOI: 10.1101/2025.06.02.25328447

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