Article

Gene signatures derived from transcriptomic-causal networks stratified colorectal cancer patients for effective targeted therapy

2023-12-15

Abstract excerpt

Predictive and prognostic gene signatures derived from interconnectivity among genes can tailor clinical care to patients in cancer treatment. We identified gene interconnectivity as the transcriptomic-causal network by integrating germline genotyping and tumor RNA-seq data from 1,165 patients with metastatic colorectal cancer (CRC). The patients were enrolled in a clinical trial with randomized treatment, either...

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Literature Corpus work: fd729d69-903e-5e37-bee8-ec8f926dea8a
DOI: 10.21203/rs.3.rs-3673588/v1

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