Article
Causal Inference and Prognostic Modeling in Colorectal Cancer through Integration of Computational Pathology and Mendelian Randomization.
Annals of surgical oncology - 1 Mar 2026
Bao Wenhao, Wang Tianying, Wang Yulin, Chen Long, Qin Fuyao, Chen Shuang, Miao Lei, Zhou Shaofei
Abstract excerpt
BACKGROUND: While traditional pathology supports the diagnosis and staging of colorectal cancer (CRC), computational pathology provides novel prognostic insights. Mendelian randomization (MR) is effective in uncovering causal relationships in cancer research; however, studies that integrate MR with pathology to investigate gut microbiota (GM), immune cells, and CRC remain limited. MATERIALS AND METHODS: We...
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