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Sexual selection by female immunity against paternal antigens can fix loss of function alleles

10 Oct 2011

Abstract excerpt

Humans lack the common mammalian cell surface molecule N-glycolylneuraminic acid (Neu5Gc) due to a CMAH gene inactivation, which occurred approximately three million years ago. Modern humans produce antibodies specific for Neu5Gc. We hypothesized that anti-Neu5Gc antibodies could enter the female reproductive tract and target Neu5Gc-positive sperm or fetal tissues, reducing reproductive compatibility. Indeed,...

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PMID: 21987817
DOI: 10.1073/pnas.1102302108

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