Article

A unique transcriptomic landscape defines African-specific grade group 1 prostate cancer

2026-04-24

Abstract excerpt

<title>Abstract</title> <p> Background Prostate cancer (PCa) exhibits significant ancestry-related disparity. While men of African ancestry experience higher overall mortality rates, this difference is most pronounced in Sub-Saharan Africa and for grade group 1 (GG1) disease, alluding to ancestry-specific biology. Despite this health disparity, African-relevant and prostate tumour GG1 inclusive data, specifical...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd503a27-63c6-5ce0-b03f-b747f88694ab
DOI: 10.21203/rs.3.rs-9384143/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A unique transcriptomic landscape defines African-specific grade group 1 prostate cancerDOI 10.21203/rs.3.rs-9384143/v1Read

African-specific molecular taxonomy of prostate cancer.Semantic proximity Read

Ancestry-defined molecular taxonomy of prostate cancer.Semantic proximity Read

African-specific prostate cancer molecular taxonomySemantic proximity Read

Alterations in the Epigenetic Machinery Associated With Prostate Cancer Health DisparitiesSemantic proximity Read

Integrated proteogenomics uncovers ancestry-specific and shared molecular drivers in localized prostate cancerSemantic proximity Read

Alterations in the Epigenetic Machinery Associated with Prostate Cancer Health DisparitiesSemantic proximity Read

Prostate cancer genetic risk and associated aggressive disease in men of African ancestrySemantic proximity Read

Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry.Semantic proximity Read

Prostate cancer genetic risk and associated aggressive disease in men of African ancestry.Semantic proximity Read

Methylation reprogramming associated with aggressive prostate cancer and ancestral disparitiesSemantic proximity Read

RNA expression differences in prostate tumors and tumor-adjacent stroma between Black and White AmericansSemantic proximity Read

Epigenome‐wide association study of prostate cancer in African American men identified differentially methylated genesSemantic proximity Read