Article

Methylation reprogramming associated with aggressive prostate cancer and ancestral disparities

2025-04-18

Abstract excerpt

African men are disproportionately impacted by aggressive prostate cancer (PCa). Key to this disparity both genetic and environmental factors, alluding to epigenetic modifications. However, African-inclusive prostate tumour DNA methylation studies are lacking. Assembling a multi-geo-ancestral prostate tissue cohort, including men with (57 African, 48 European, 23 Asian) or without (65 African) PCa, we interrogate...

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Literature Corpus work: a7552426-a101-5943-82f7-ebdee941255a
DOI: 10.1101/2025.04.16.649098

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