Article

Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells.

2024-01-24

Abstract excerpt

<title>Abstract</title> <p>Mutations in Tissue Inhibitor of Metalloproteinases 3 (TIMP3) cause Sorsby’s Fundus Dystrophy (SFD), a dominantly inherited, rare form of macular degeneration that results in vision loss. TIMP3 is synthesized primarily by retinal pigment epithelial (RPE) cells, which constitute the outer blood-retinal barrier. Quantitative proteomics and RNAseq analysis on the choroid/RPE of mice expres...

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Literature Corpus work: 0d7ebf53-f66b-53b7-8a8e-3593b0fbc999
DOI: 10.21203/rs.3.rs-3838373/v1

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