Article
The retinal pigment epithelium in Sorsby Fundus Dystrophy shows increased sensitivity to oxidative stress-induced degeneration.
Redox biology - 1 Oct 2020
Wolk Alyson, Upadhyay Mala, Ali Mariya, Suh Jason, Stoehr Heidi, Bonilha Vera L, Anand-Apte Bela
Abstract excerpt
Sorsby Fundus Dystrophy (SFD) is a rare inherited autosomal dominant macular degeneration caused by specific mutations in TIMP3. Patients with SFD present with pathophysiology similar to the more common Age-related Macular Degeneration (AMD) and loss of vision due to both choroidal neovascularization and geographic atrophy. Previously, it has been shown that RPE degeneration in AMD is due in part to oxidative...
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