Article
TIMP-3, collagen, and elastin immunohistochemistry and histopathology of Sorsby's fundus dystrophy.
Investigative ophthalmology & visual science - 1 Mar 2000
Chong N H, Alexander R A, Gin T, Bird A C, Luthert P J
Abstract excerpt
PURPOSE: Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP-3) gene have previously been identified in patients with Sorsby's fundus dystrophy (SFD). We evaluated the ocular distribution of TIMP-3 and other extracellular constituents in SFD. METHODS: The eyes of an SFD donor with a confirmed TIMP-3 mutation were examined using histologic techniques demonstrating connective tissue, calcium, and lipid....
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