Article

Functional Characterization of the Hephaestin Variant D568H Provides Novel Mechanistic Insights on Iron‐Dependent Asbestos‐Induced Carcinogenesis

2025-02-08

Abstract excerpt

Local disruption of iron homeostasis leading to oxidative stress is considered one of the main mechanisms of asbestos-dependent cyto-/genotoxicity. Another aspect contributing to the risk of developing pathological consequences upon asbestos exposure is due to individual genetic fac-tors. In a previous study we identified a coding SNP in the hephaestin gene (HEPH) exerting a protective activity against the develop...

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Literature Corpus work: fcc598a9-b356-5381-a461-e574e1c31ac6
DOI: 10.20944/preprints202502.0580.v1

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