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Divergent lineage trajectories and genetic landscapes in human gastric intestinal metaplasia organoids associated with early neoplastic progression

2024-04-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Gastric intestinal metaplasia (IM) is a pre-cancerous stage spanning a morphological spectrum that is poorly represented by human cell line models. We aim to establish and characterize human IM cell models to better understand IM progression along the cancer spectrum. <h4>Design</h4> A large human gastric IM organoid (IMO) cohort (n=28) was established, along with normal gas...

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Literature Corpus work
f7e49a3d-5414-5792-9bd1-47b2dbbaf29e
DOI
10.1101/2024.04.03.588024
Open publication

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Divergent lineage trajectories and genetic landscapes in human gastric intestinal metaplasia organoids associated with early neoplastic progressionDOI 10.1101/2024.04.03.588024
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