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The miR-362-3p/ <i>BCLAF1</i> axis regulates cisplatin sensitivity and metastatic progression in triple-negative breast cancer

2026-03-10

Abstract excerpt

Platinum-based chemotherapy remains a cornerstone of treatment for triple-negative breast cancer (TNBC), yet the molecular determinants governing platinum response remain poorly defined. By leveraging the randomized Phase II INFORM trial, which compared neoadjuvant cisplatin to anthracycline-based therapy in BRCA1/2 -mutant breast cancer—we identified miR-362-3p as a specific regulator of cisplatin sensitivity. H...

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Literature Corpus work
fcc2796e-4f04-5d68-9241-48120ed94dd5
DOI
10.64898/2026.03.09.26347941
Open publication

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