Article

Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression

2023-07-09

Abstract excerpt

Neuronal inclusions comprised of aggregated alpha-synuclein (αsyn) represent a key histopathological feature of neurological disorders collectively termed “synucleinopathies”, which includes Parkinson’s disease (PD). Mutations and amplifications in the SNCA gene encoding αsyn cause familial forms of PD and a large body of evidence indicate a correlation between αsyn accumulation and disease. Decreasing αsyn expre...

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Literature Corpus work: fcbf4910-f18e-56bb-a086-1ddbd21ef4cf
DOI: 10.1101/2023.07.06.547988

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