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Article

Aβ exacerbates α-synuclein-induced neurotoxicity through impaired insulin signaling in α-synuclein-overexpressed human SK-N-MC neuronal cells.

CNS neuroscience & therapeutics - 1 Jan 2018

Chang Ching-Chi, Li Hsin-Hua, Chang Yen-Ting, Ho Ying-Jui, Hsieh Ling-Jia, Chiu Pai-Yi, Cheng Yu-Shih, Lin Chih-Li, Lai Te-Jen

Abstract excerpt

AIM: α-Synuclein (αSyn) is known as a small soluble protein abundantly expressed in neuronal cells. Although its physiological role is still unclear, the aggregation of αSyn has been recognized as responsible for some neurodegenerative disorders such as dementia with Lewy bodies (DLB). In most cases, intracellular abnormal aggregates are caused by protein-coding mutations that alter primary structure and...

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PMID: 29092095
DOI: 10.1111/cns.12772
PMCID: PMC6489723

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