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Article

The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy.

Structure (London, England : 1993) - 1 Jun 2002

Krimm Isabelle, Ostlund Cecilia, Gilquin Bernard, Couprie Joël, Hossenlopp Paul, Mornon Jean-Paul, Bonne Gisèle, Courvalin Jean-Claude, Worman Howard J, Zinn-Justin Sophie

Abstract excerpt

Lamins are nuclear intermediate filaments that, together with lamin-associated proteins, maintain nuclear shape and provide a structural support for chromosomes and replicating DNA. We have determined the solution structure of the human lamin A/C C-terminal globular domain which contains specific mutations causing four different heritable diseases. This domain encompasses residues 430-545 and adopts an Ig-like...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12057196
DOI: 10.1016/s0969-2126(02)00777-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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