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Article

Common developmental genome deprogramming in schizophrenia - Role of Integrative Nuclear FGFR1 Signaling (INFS).

Schizophrenia research - 1 Jul 2017

Narla S T, Lee Y-W, Benson C A, Sarder P, Brennand K J, Stachowiak E K, Stachowiak M K

Abstract excerpt

The watershed-hypothesis of schizophrenia asserts that over 200 different mutations dysregulate distinct pathways that converge on an unspecified common mechanism(s) that controls disease ontogeny. Consistent with this hypothesis, our RNA-sequencing of neuron committed cells (NCCs) differentiated from established iPSCs of 4 schizophrenia patients and 4 control subjects uncovered a dysregulated transcriptome of...

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Identifiers

PMID: 28094170
DOI: 10.1016/j.schres.2016.12.012
PMCID: PMC5507209

Genes

FGFR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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