Article

Alternative splicing of SLAMF6 in human T cells creates a co-stimulatory isoform that counteracts the inhibitory effect of the full-length receptor

2020-08-22

Abstract excerpt

<h4>ABSTRACT</h4> SLAMF6 is a homotypic receptor of the Ig-superfamily associated with progenitor exhausted T cells. In humans, SLAMF6 has three splice isoforms involving its V-domain. While the canonical 8-exon receptor inhibits T cell activation through SAP recruitment, the short isoform SLAMF6 Δ17-65 has a strong agonistic effect. The costimulatory action depends on protein phosphatase SHP-1 and leads to a cy...

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Literature Corpus work: fc66f937-fad2-512d-b67c-d28af68ff59d
DOI: 10.1101/2020.08.21.262238

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