Article

Processing UMI Datasets at High Accuracy and Efficiency with the Sentieon ctDNA Analysis Pipeline

2022-06-05

Abstract excerpt

Liquid biopsy enables identification of low allele frequency (AF) tumor variants and novel clinical applications such as minimum residual disease (MRD) monitoring. However, challenges remain, primarily due to limited sample volume and low read count of low-AF variants. Because of the low AFs, some clinically significant variants are difficult to distinguish from errors introduced by PCR amplification and sequencin...

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Literature Corpus work: 8b582fb3-dd92-5475-9cc1-24a0c3a83ee5
DOI: 10.1101/2022.06.03.494742

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