CRISPR/Cas9 gene drives in genetically variable and non-randomly mating wild populations

Abstract excerpt

Synthetic gene drives based on CRISPR/Cas9 have the potential to control, alter or suppress populations of crop pests and disease vectors, but it is unclear how they will function in wild populations. Using genetic data from four populations of the flour beetle Tribolium castaneum , we show that most populations harbor genetic variants in Cas9 target sites, some of which would render them immune to drive (ITD). W...

Topics

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• Clustered Regularly Interspaced Short Palindromic Repeats
• CRISPR-Cas Systems
• Gene Editing
• Genetic Variation
• Models, Genetic
• Reproduction
• RNA, Guide, CRISPR-Cas Systems
• Tribolium

Identifiers and source

Literature Corpus work

fc447748-d8cd-52a3-adc0-d4e61f29e869

DOI

10.1101/071670