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Mutations in the TRS Region Alter Coronavirus (Porcine Epidemic Diarrhea Virus) Replication and Interferon Induction by Modulating Subgenomic RNA Transcription

2025-09-15

Abstract excerpt

Coronaviruses frequently cause epidemics of respiratory or enteric disease in humans and livestock. CoVs generate a nested set of subgenomic messenger RNAs (sgmRNAs) through discontinuous transcription mediated by transcription regulatory sequences (TRSs). We previously developed a porcine epidemic diarrhea virus (PEDV) mutant, RMT, by remodeling TRS-core sequences (TRS-CSs). Unexpectedly, plasmid mutagenesis intr...

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Literature Corpus work
fc233b11-0dc3-5044-ac57-8574edbf18fd
DOI
10.20944/preprints202509.1182.v1
Open publication

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