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Article

Engineering a recombination-resistant live attenuated vaccine candidate with suppressed interferon antagonists for PEDV.

Journal of virology - 22 Jul 2025

Liu Mingde, Aryal Bikash, Niu Xiaoyu, Wang Qiuhong

Abstract excerpt

Porcine epidemic diarrhea virus (PEDV) is a deadly coronavirus (CoV) for neonatal piglets, and no effective vaccine is available. Live attenuated vaccines (LAVs) show promise, but risks of recombination and reversion to virulence hinder their application. For LAV development, we previously engineered a recombination-resistant PEDV mutant RMT by rewiring the transcriptional regulatory sequence (TRS)-core sequences...

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Identifiers

PMID: 40503881
DOI: 10.1128/jvi.00451-25
PMCID: PMC12282079

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