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Genetic and Epigenetic Characterization of Sarcoma Stem Cells Across Subtypes Identifies EZH2 as a Therapeutic Target

2024-05-14

Abstract excerpt

High-grade complex karyotype soft tissue sarcomas (STS) are a heterogeneous and aggressive set of cancers that share a common treatment strategy. Disease progression and failure to respond to anthracycline based chemotherapy, standard first-line treatment, is associated with poor patient outcomes. To address this, we investigated the contribution of STS cancer stem cells (STS-CSCs) to doxorubicin resistance. We id...

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Literature Corpus work
fc1181ba-d9cf-5a2a-b6b1-87750c5c901b
DOI
10.1101/2024.05.14.594060
Open publication

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Genetic and Epigenetic Characterization of Sarcoma Stem Cells Across Subtypes Identifies EZH2 as a Therapeutic TargetDOI 10.1101/2024.05.14.594060
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