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Article

EZH2 regulates a SETDB1/ΔNp63α axis via RUNX3 to drive a cancer stem cell phenotype in squamous cell carcinoma.

Oncogene - 1 Aug 2022

Balinth Seamus, Fisher Matthew L, Hwangbo Yon, Wu Caizhi, Ballon Carlos, Sun Xueqin, Mills Alea A

Abstract excerpt

Enhancer of zeste homolog 2 (EZH2) and SET domain bifurcated 1 (SETDB1, also known as ESET) are oncogenic methyltransferases implicated in a number of human cancers. These enzymes typically function as epigenetic repressors of target genes by methylating histone H3 K27 and H3-K9 residues, respectively. Here, we show that EZH2 and SETDB1 are essential to proliferation in 3 SCC cell lines, HSC-5, FaDu, and Cal33....

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 3 Subunit

Share to Enhancer of Zeste Homolog 2 Protein

Share to Histone-Lysine N-Methyltransferase

Share to Neoplastic Stem Cells

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Source

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Identifiers

PMID: 35864175
DOI: 10.1038/s41388-022-02417-4
PMCID: PMC10132824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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