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Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with its human endosomal receptor NPC1

2 Feb 2025

Abstract excerpt

Sudan ebolavirus (SUDV), like Ebola ebolavirus (EBOV), poses a significant threat to global health and security due to its high lethality. However, unlike EBOV, there are no approved vaccines or treatments for SUDV, and its structural interaction with the endosomal receptor NPC1 remains unclear. This study compares the glycoproteins of SUDV and EBOV (in their proteolytically primed forms) and their binding to...

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PMID: 39894818
DOI: 10.1038/s42003-025-07613-y

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