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Article

Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.

Cancer discovery - 1 Jul 2013

Lui Vivian W Y, Hedberg Matthew L, Li Hua, Vangara Bhavana S, Pendleton Kelsey, Zeng Yan, Lu Yiling, Zhang Qiuhong, Du Yu, Gilbert Breean R, Freilino Maria, Sauerwein Sam, Peyser Noah D, Xiao Dong, Diergaarde Brenda, Wang Lin, Chiosea Simion, Seethala Raja, Johnson Jonas T, Kim Seungwon, Duvvuri Umamaheswar, Ferris Robert L, Romkes Marjorie, Nukui Tomoko, Kwok-Shing Ng Patrick, Garraway Levi A, Hammerman Peter S, Mills Gordon B, Grandis Jennifer R

Abstract excerpt

Genomic findings underscore the heterogeneity of head and neck squamous cell carcinoma (HNSCC). Identification of mutations that predict therapeutic response would be a major advance. We determined the mutationally altered, targetable mitogenic pathways in a large HNSCC cohort. Analysis of whole-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23619167
DOI: 10.1158/2159-8290.CD-13-0103
PMCID: PMC3710532

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23619167-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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