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Article

The influence of PI3K inhibition on the radiotherapy response of head and neck cancer cells

1 Oct 2020

Abstract excerpt

Radiotherapy has a central role in the treatment of head and neck squamous cell carcinoma (HNSCC). Activation of the PI3K/AKT/mTOR pathway can decrease the efficiency of radiotherapy via the promotion of cell survival and DNA repair. Here, the influence of PI3K pathway inhibition on radiotherapy response was investigated. Two PI3K inhibitors were investigated and both BKM120 and GDC0980 effectively inhibited...

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PMID: 33004905
DOI: 10.1038/s41598-020-73249-z

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