Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular pathways in head and neck cancer: EGFR, PI3K, and more.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting - 1 Jan 2013

Psyrri Amanda, Seiwert Tanguy Y, Jimeno Antonio

Abstract excerpt

The treatment of head and neck squamous cell carcinoma (HNSCC) is set to undergo rapid changes, as novel treatment targets informed by genomic profiling and novel molecularly targeted therapies continue to make strides. In this review we provide an overview of the latest developments regarding (1) EGFR targeting for HNSCC, (2) PI3K as a novel treatment target, and (3) newly described key genetic events in HNSCC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activin Receptors, Type II
Share to Cetuximab

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Epithelial-Mesenchymal Transition

Share to Head and Neck Neoplasms

Share to Hedgehog Proteins

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Receptor, Notch1

Source

Identifiers

PMID: 23714515
DOI: 10.14694/EdBook_AM.2013.33.246

Genes

EGFR
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular pathways in head and neck cancer: EGFR, PI3K, and more.PMID 23714515Read ↗

EGFR–PI3K–AKT–mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapySemantic proximity Read ↗

Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC)Semantic proximity Read ↗

The PI3K/Akt/mTORC signaling axis in head and neck squamous cell carcinoma: Possibilities for therapeutic interventions either as single agents or in combination with conventional therapiesSemantic proximity Read ↗

Application of molecular targeted therapies in the treatment of head and neck squamous cell carcinoma (Review)Semantic proximity Read ↗

Exploiting the Head and Neck Cancer Oncogenome: Widespread PI3K-mTOR Pathway Alterations and Novel Molecular TargetsSemantic proximity Read ↗

Molecular changes in the multistage pathogenesis of head and neck cancerSemantic proximity Read ↗

Sequencing the head and neck cancer genome: implications for therapy.Semantic proximity Read ↗

EGFR and PI3K Pathway Activities Might Guide Drug Repurposing in HPV-Negative Head and Neck CancersSemantic proximity Read ↗

Is biomarker research advancing in the era of personalized medicine for head and neck cancer?Semantic proximity Read ↗

Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer.Semantic proximity Read ↗

Integrating genomics in head and neck cancer treatment: Promises and pitfalls.Semantic proximity Read ↗

Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.