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A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants

3 Nov 2021

Abstract excerpt

The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years. The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants. Here we show that the bivalency of an affinity maturated fully human single-domain antibody (n3113.1-Fc) exhibits...

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PMID: 34732694
DOI: 10.1038/s41392-021-00810-1

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