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Killer instincts: natural killer cells as multifactorial cancer immunotherapy

28 Nov 2023

Abstract excerpt

Natural killer (NK) cells integrate heterogeneous signals for activation and inhibition using germline-encoded receptors. These receptors are stochastically co-expressed, and their concurrent engagement and signaling can adjust the sensitivity of individual cells to putative targets. Against cancers, which mutate and evolve under therapeutic and immunologic pressure, the diversity for recognition provided by NK...

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PMID: 38090565
DOI: 10.3389/fimmu.2023.1269614

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