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Human nasal and lung tissues infected <i>ex vivo</i> with SARS-CoV-2 provide insights into differential tissue-specific and virus-specific innate immune responses in the upper and lower respiratory tract

2021-03-08

Abstract excerpt

<h4>ABSTRACT</h4> The nasal-mucosa constitutes the primary entry site for respiratory viruses including SARS-CoV-2. While the imbalanced innate immune response of end-stage COVID-19 has been extensively studied, the earliest stages of SARS-CoV-2 infection at the mucosal entry site have remained unexplored. Here we employed SARS-CoV-2 and influenza virus infection in native multi-cell-type human nasal turbinate an...

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Literature Corpus work: fbc03b69-257f-5638-a5c1-713229fd692a
DOI: 10.1101/2021.03.08.434404

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