Article

Direct control of translational elongation by TAOK2β highlights altered protein synthesis as a fundamental underlying component of autism

2022-08-23

Abstract excerpt

Microdeletions in the 16p11.2 region of the human genome are frequently associated with autism spectrum disorders (ASDs), but how these genomic rearrangements cause ASD remains unclear. Here, we reveal that TAOK2β, a protein isoform encoded by the human TAOK2 gene located in the 16p11.2 locus, regulates mRNA translation. To identify key functional interaction partners of TAOK2β, we performed proteomic screening...

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Literature Corpus work: fbb06213-02cd-5311-815e-cb87da3b835f
DOI: 10.1101/2022.08.22.504812

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