Article

Loss of MAGEL2 Disrupts Pituitary Translation in a Mouse Model of PWS and Schaaf–Yang Syndrome

2026-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Prader-Willi syndrome (PWS) and Schaaf-Yang syndrome (SYS) are neurodevelopmental disorders associated with hypothalamic-pituitary dysregulation. In the pituitary gland, translational control enables rapid peptide hormone production and secretion in response to hypothalamic signals without requiring new mRNA synthesis, yet the mechanisms regulating pituitary translation remain poorly understood....

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Literature Corpus work: 8074eeed-4fc0-5ff1-9f55-77e85ff1caf0
DOI: 10.64898/2026.05.12.724462

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