Article
Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression.
Molecular medicine (Cambridge, Mass.) - 1 Jan 1999
Chen L, Lu W, Agrawal S, Zhou W, Zhang R, Chen J
Abstract excerpt
BACKGROUND: The MDM2 oncogene functions as a negative feedback regulator of the p53 tumor suppressor. Abnormal expression of MDM2 in tumors may attenuate the p53-mediated growth arrest and apoptosis response, resulting in increased cell proliferation and resistance to chemotherapy. MATERIALS AND METHODS: We have developed phosphorothioate antisense oligodeoxynucleotides optimized for inhibition of MDM2 expression...
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