Article
Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of presenilin 1.
Human molecular genetics - 11 Aug 2020
Newman Morgan, Nik Hani Moussavi, Sutherland Greg T, Hin Nhi, Kim Woojin S, Halliday Glenda M, Jayadev Suman, Smith Carole, Laird Angela S, Lucas Caitlin W, Kittipassorn Thaksaon, Peet Dan J, Lardelli Michael
Abstract excerpt
Ageing is the major risk factor for Alzheimer's disease (AD), a condition involving brain hypoxia. The majority of early-onset familial AD (EOfAD) cases involve dominant mutations in the gene PSEN1. PSEN1 null mutations do not cause EOfAD. We exploited putative hypomorphic and EOfAD-like mutations in the zebrafish psen1 gene to explore the effects of age and genotype on brain responses to acute hypoxia. Both...
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