Article

Transcriptional Profiling of Commonly Used Liver Cancer Cell Lines Reveals Disease-Specific Modeling Potential and Authentication Concerns

2025-10-31

Abstract excerpt

Cell lines are essential tools for liver cancer research, yet their molecular fidelity to primary tumors remains incompletely characterized. Here we comprehensively evaluated transcriptomic similarities between commonly used liver cancer cell lines and primary tumor subtypes to guide optimal model selection. We analyzed RNA sequencing data from 541 samples spanning primary HCC, HPBL, CHOL, and FLC tumors, alongsid...

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Literature Corpus work: fb7f16b7-8b00-59b2-9edd-270264ba3c7a
DOI: 10.1101/2025.10.30.685599

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