Article

Metacells untangle large and complex single-cell transcriptome networks

2021-06-08

Abstract excerpt

The exponential scaling of scRNA-seq data represents an important hurdle for downstream analyses. Here we develop a coarse-graining framework where highly similar cells are merged into metacells. We demonstrate that metacells not only preserve but often improve the results of downstream analyses including visualization, clustering, differential expression, cell type annotation, gene correlation, imputation, RNA ve...

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Literature Corpus work: 0cd442cc-e7b8-51c0-905d-58c8e5427987
DOI: 10.1101/2021.06.07.447430

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