Article

The Na + /H + exchanger NHE3 inhibitor tenapanor prevents intestinal obstructions in CFTR-deleted mice

2022-05-25

Abstract excerpt

Background and purpose: Mutations in the CFTR chloride channel result in intestinal o-structive episodes in cystic fibrosis (CF) patients and in CF animal models. This study explores the possibility of reducing the frequency of obstructive episodes in the Cftr -/- mice by the oral application of a gut selective NHE3 inhibitor tenapanor and searches for the underlying mechanisms involved. Experimental approach: Se...

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Literature Corpus work: fb6c82f7-af12-51db-922c-930dafea363c
DOI: 10.22541/au.165348030.02708198/v1

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