Article

Evaluating the Sex Dependent Influence of Sarcospan on Cardiometabolic Disease Traits in Mice

2024-04-01

Abstract excerpt

Numerous genes including sarcospan (SSPN) have been designated as obesity-susceptibility genes by human genome-wide association studies. Variants in the sarcospan (SSPN) gene locus have been associated with obesity traits with a stronger effect in women. To date this association has not been tested in vivo, therefore, we assessed the susceptibility of young (2 month) global SSPN-deficient (SSPN -/- ) mice to diet...

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Literature Corpus work: 0785b818-6c4d-561d-9463-20f3bd378667
DOI: 10.1101/2024.03.31.586423

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