Article

Pharmacological weight loss with incretin-based therapies does not result in a disproportionate loss of muscle mass or function in obese mice and humans

2025-07-28

Abstract excerpt

The new generation of incretin-based therapies are potent anti-obesity medications (AOMs) that offer the first non-surgical treatment for 936 million patients globally suffering from being overweight or obese[1]. However, clinical data suggest that incretin-mimetics could cause a disproportionate decrease in lean body mass (LBM) [2, 3], raising a concern for deterioration of skeletal muscle and acceleration of sar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c2d04ad1-fed3-56a1-bbc9-2a0b828e67d8
DOI: 10.1101/2025.07.28.25332295

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pharmacological weight loss with incretin-based therapies does not result in a disproportionate loss of muscle mass or function in obese mice and humansDOI 10.1101/2025.07.28.25332295Read

Females are protected from semaglutide-induced muscle loss in <i>ob/ob</i> miceSemantic proximity Read

Manipulation of health span and function by dietary caloric restriction mimeticsSemantic proximity Read

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscleSemantic proximity Read

AlfaDAX-Derived ActRIIA/B Antibody with Semaglutide Enhances Fat Loss and Improves Weight-Loss Quality in DIO MiceSemantic proximity Read

A dietary intervention following incretin analog treatment restores adipose tissue functions in diet-induced obese miceSemantic proximity Read

Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sportSemantic proximity Read

Caloric Restriction, Physical Exercise, and CB1 Receptor Blockade as an Efficient Combined Strategy for Bodyweight Control and Cardiometabolic Status Improvement.Semantic proximity Read

Insulin Resistance Mediates Crosstalk between Skeletal Muscle and the Heart to Prevent Cardiac DysfunctionSemantic proximity Read

Micro(RNA)-managing muscle wastingSemantic proximity Read

HIIT discontinuation may be detrimental to diabesity parameters whereas retraining enhances intestinal health and gut microbiota diversitySemantic proximity Read

A low protein diet drives short-and long-term improvements in metabolic health in a mouse model of sleeve gastrectomySemantic proximity Read

Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse modelSemantic proximity Read